PRESS RELEASES

• SignalGene completes the acquisition of Dope.de June 21, 2000
  
  
• GUARD announces transaction with SignalGene May 9, 2000
  
  
• GUARD announces first revenues for Dope.de March 7, 2000
  
  
• Dope.de Develops New Optimized Antiestrogen Leads from Computer-Aided de novo Design December 2, 1999
  
  
• Nexia CEO Dr. Jeffrey Turner Joins the Board of Dope.de September 23, 1999
  
  
• Dope.de Appoints New President and CEO September 22, 1999
  
  
• Dope.de Achieves Major Milestone in its Drug Design Technology May 26, 1999